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Prognostic significance of the NPM-ALK fusion gene in bone marrow and peripheral blood for patients with anaplastic large cell lymphoma / 中华血液学杂志
Chinese Journal of Hematology ; (12): 700-703, 2013.
Article in Chinese | WPRIM | ID: wpr-272134
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of NPM- ALK fusion gene in bone marrow (BM) and peripheral blood (PB) in anaplastic large cell lymphoma (ALCL) patients and its prognostic significance.</p><p><b>METHODS</b>NPM- ALK fusion gene of 21 BM and 15 PB samples from patients with NPM-ALK positive ALCL was detected by RT- PCR, and the relationship between NPM- ALK expression and prognosis and clinical characters was evaluated.</p><p><b>RESULTS</b>Of the 21 patients, 12 cases were male and 9 case were female with a median age of 9 (range, 2-14) years old. The median follow- up was 31 months. Patients with a positive NPM-ALK expression in BM had a 3-years EFS of (35.6±18.6)%, compared with (91.7±8.0)% for patients with negative NPM-ALK (P=0.038). The incidence of positive expression in BM was significantly higher in patients who had more than 3 organs involved by tumor (P=0.032). 86.7% patients had a concordant results of NPM-ALK expression in PB and BM.</p><p><b>CONCLUSION</b>We could evaluate the minimal disseminated disease of NPM-ALK positive ALCL patients by screening the NPM-ALK fusion gene in BM and PB by RT-PCR. The positive expression is associated with a poor prognosis and could be used for stratification of ALCL.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Bone Marrow / Protein-Tyrosine Kinases / Lymphoma, Large-Cell, Anaplastic / Diagnosis / Genetics / Metabolism Type of study: Diagnostic study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hematology Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Bone Marrow / Protein-Tyrosine Kinases / Lymphoma, Large-Cell, Anaplastic / Diagnosis / Genetics / Metabolism Type of study: Diagnostic study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hematology Year: 2013 Type: Article