l-myc Polymorphism in Gastric Cancer, Lung Cancer, and Hepatocellular Carcinoma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 436-438, 2002.
Article
in English
| WPRIM
| ID: wpr-27227
ABSTRACT
PURPOSE:
This study was performed to see if a particular polymorphism in the l-myc, a nuclear oncogene at the 1p32 locus, might be associated with greater risk of gastric cancer, lung cancer and hepatocellular carcinomas (HCC) in Korean patients. MATERIALS ANDMETHODS:
Genomic DNA, derived from patients diagnosed with gastric cancer (n=57), lung cancer (n=39), HCC (n=35) and healthy individuals (n= 176), was examined. The l-myc polymorphism under study was visualized by PCR followed by EcoRI digestion.RESULTS:
There was no significant difference in the distribution of the l-myc polymorphism genotypes and allele frequencies between the cancer patients and the controls.CONCLUSION:
The l-myc polymorphism does not appear to be indicative of elevated risk of cancers of the stomach, lung and HCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Stomach
/
Stomach Neoplasms
/
DNA
/
Polymerase Chain Reaction
/
Carcinoma, Hepatocellular
/
Digestion
/
Gene Frequency
/
Genotype
/
Lung
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2002
Type:
Article
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