Expression and significance of bone sialoprotein(BSP) in esophageal squamous cell carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 602-605, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-272327
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the roll of bone sialoprotein (BSP), a secreted glycoprotein, found in mineralized tissues in the development and progression of human esophageal squamous cell carcimoma (ESCC), and explore its association with clinicopathological characteristics and five-year survival of the patients.</p><p><b>METHODS</b>The expression of BSP was determined in 211 primary ESCC tumors and their paired nontumorous tissues using tissue-array, RT-PCR and immunohistochemistry.</p><p><b>RESULTS</b>Primary ESCC tissues showed a significantly higher expression rate of BSP mRNA than their paired nontumorous tissues (93.8% vs. 16.6%, P < 0.001), the same with BSP protein (56.9% vs. 31.3%, P < 0.001). The expression rate of BSP protein was correlated to lymph node metastasis and TNM stage (P < 0.05). The 5-year survival rate of BSP protein-positive ESCC patients was significantly lower than that of BSP protein-negative ESCC patients (P < 0.05). Multivariate analysis showed that tumor differentiation, TNM staging and BSP protein expression were independent factors affecting the prognosis of ESCC patients (P < 0.05).</p><p><b>CONCLUSIONS</b>The abnormal expression of BSP may play a significant role in the malignant progression and prognosis of ESCC, and BSP might be a marker reflecting the biologial behavior of ESCC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
RNA, Messenger
/
Esophageal Neoplasms
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Blotting, Western
/
Survival Rate
/
Diagnosis
/
Integrin-Binding Sialoprotein
/
Genetics
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2014
Type:
Article
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