A Case of Acquired Perforating Dermatosis Associated with Hepatocellular Carcinoma and Diabetic Nephropathy / 대한피부과학회지

ABSTRACT

Acquired perforating dermatosis is a perforating disorder associated with diabetic mellitus or renal failure, which is characterized by transepidermal elimination of altered collagen and by its occurrence in adult life. We present a case of acquired perforating dermatosis associated with hepatocellular carcinoma and diabetic nephropathy, who had multiple pruritic brownish papules and nodules on trunk and extremities for 2 months. Histological findings showed transepidermal channel containing fragmented collagen and elastic fibers. The skin lesions were disappeared one month after hepatic lobetomy. It indicates that hepatocellular carcinoma can be one of the etiological factors in the development of acquired perforating dermatosis.