Relationship between TIM-4 polymorphism and childhood asthma / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 120-123, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-272377
ABSTRACT
<p><b>OBJECTIVE</b>To elucidate whether the polymorphism of asthma immune regulator gene TIM-4 is associated with the risk of childhood allergic asthma in the southwest region of China.</p><p><b>METHODS</b>TIM-4 gene promoter region RS6882076 and intron RS4704727 were studied. PCR-RFLP was used to test the genotypes of two polymorphism loci among 579 cases (average 7.2 years old) of asthma and 524 controls (average 7.6 years old) in a case-control study.</p><p><b>RESULTS</b>There were significant differences in the frequency of gene types at RS4704727 site between the asthma and the control groups (P<0.01). The results of PCR-RFLP showed that the polyporphisms of RS6882076 and RS4704727 in TIM-4 gene were present in this study population. The frequency of T allele at the RS4704727 site in the asthma group was significantly lower than that in the control group (OR=1.603; 95%CI 1.304-1.971; P<0.01). There were no significant differences in the frequencies of gene types and allele at RS6882076 site between the two groups (P>0.05).</p><p><b>CONCLUSIONS</b>RS4704727 polymorphism of TIM-4 gene may be associated with childhood asthma, providing a better understanding of the pathogenesis of childhood asthma in the Southwest region of China.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Promoter Regions, Genetic
/
Polymorphism, Single Nucleotide
/
Genetics
/
Membrane Proteins
Type of study:
Observational study
Limits:
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2012
Type:
Article
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