Risk factors and pathogen distribution in premature infants with nosocomial sepsis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 93-96, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-272384
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the main risk factors and pathogen distribution of nosocomial sepsis among premature infants.</p><p><b>METHODS</b>The clinical data of 3418 hospitalized premature infants from January 2003 to December 2010 were retrospectively analyzed for the risk factors and pathogen distribution of nosocomial sepsis.</p><p><b>RESULTS</b>The incidence of neonatal nosocomial sepsis was 3.10% (106/3418), and the median age at diagnosis of neonatal nosocomial sepsis was 19 (4-48) days. The major pathogens of the infections among these premature infants included gram-positive bacteria (45.2%), especially coagulase-negative Staphylococcus (24.3%), and gram-negative bacteria (41.7%), especially Klebsiella pneumoniae (25.2%), as well as fungus (13.0%). Logistic regression analysis showed that the main risk factors included low birth weight, retention of central venous catheters, and long duration of parenteral nutrition (OR 3.765, 3.051, and 2.998, respectively; P<0.05).</p><p><b>CONCLUSIONS</b>Low birth weight, retention of central venous catheters, and long duration of parenteral nutrition are the main risk factors for neonatal nosocomial sepsis, whereas the leading pathogen is Klebsiella pneumoniae.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacteria
/
Birth Weight
/
Infant, Premature
/
Catheterization, Central Venous
/
Logistic Models
/
Cross Infection
/
Retrospective Studies
/
Risk Factors
/
Parenteral Nutrition
/
Sepsis
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2012
Type:
Article
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