Association between single nucleotide polymorphism of insulin-like growth factor receptor gene and idiopathic short stature / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 955-958, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-272423
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between single nucleotide polymorphism (SNP) of insulin-like growth factor I receptor (IGF-IR) gene and idiopathic short stature (ISS).</p><p><b>METHODS</b>A total of 804 children with ISS and 575 normal controls were recruited from 2008 to 2011. IGF-IR gene SNP was genotyped using the Snapshot Multiplex System.</p><p><b>RESULTS</b>The distribution frequency of genotype rs1976667 showed no significant difference between the ISS and the control groups, while that of the allele A of rs1976667 was significantly higher in the ISS group than in the control group (P<0.01).</p><p><b>CONCLUSIONS</b>The allele A at rs1976667 SNP of IGF-IR gene is a risk factor for ISS.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Receptor, IGF Type 1
/
Polymorphism, Single Nucleotide
/
Genetics
/
Growth Disorders
Type of study:
Risk factors
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2011
Type:
Article
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