Changes of regulatory T cells in the peripheral blood of children with epilepsy / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 889-892, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-272441
ABSTRACT
<p><b>OBJECTIVE</b>To study the levels of CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) in the peripheral blood of children with epilepsy and the roles of Tregs in the pathogenesis of epilepsy.</p><p><b>METHODS</b>Forty-one children with epilepsy and thirty-eight healthy children were enrolled. The percentage of CD4+ CD25+ Foxp3+ Tregs in CD4+ T cells and the percentages of CD4+ T cells, CD8+ T cells, nature killer (NK) cells and B cells in lymphocytes were evaluated by flow cytometry.</p><p><b>RESULTS</b>The percentages of peripheral blood CD4+ CD25+ Foxp3+ Tregs and CD4+ T cells and the ratio of CD4+ T cells to CD8+ T cells in epileptic children were (2.4±0.5)%, (35±5)% and 1.32±0.24 respectively, which were significantly lower than those in healthy children [(6.1±1.2)%, (38±4)% and 1.60±0.24 respectively; P<0.05]. In contrast, the percentages of CD8+ T cells, NK cells and B cells in lymphocytes in epileptic children were significantly higher than those in healthy children[(27±3)% vs (24±3)%, (11.1±5.1)% vs (8.5±1.9)% and (24±9)% vs (16±5)% respectively; P<0.05].</p><p><b>CONCLUSIONS</b>The abnormal percentage of CD4+ CD25+ Foxp3+ Tregs in the peripheral blood may be involved in the pathogenesis of epilepsy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Killer Cells, Natural
/
CD4-CD8 Ratio
/
T-Lymphocytes, Regulatory
/
Allergy and Immunology
/
Epilepsy
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2011
Type:
Article
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