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Role of SOX7 in Hematopoietic System Development and Hematological Malignancies--Review / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 233-236, 2016.
Article in Chinese | WPRIM | ID: wpr-272472
ABSTRACT
The sex-determining region Y-box 7 (Sox7) is a important member of SOX family containing high mobi- lity group (HMG), mapped to human chromosome 8p23.1. Wnt/β-catenin signaling pathway plays an important role in cell survival, differentiation, self-renewal, proliferation and apoptosis, and is closely related with carcinogenesis. SOX7 gene is likely to be a tumor suppressor gene in MDS and other hematological malignancies. As a negative regulator of the WNT/β-catenin signaling pathway, the function loss of this gene can lead to carcinogenesis. The methylation of SOX7 gene leads to the silence of this gene, resulting in tumorigenesis. The decision of hematopoietic stem cells to self-renew or differentiate is a stochastic process, but SOX7 can promote the differentiation into all blood cell types. This review focuses on the role of SOX7 in hematopoietic system development and hematological malignancies.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Hematologic Neoplasms / DNA Methylation / Gene Silencing / SOXF Transcription Factors / Wnt Signaling Pathway / Genetics / Hematopoietic System / Metabolism Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Hematologic Neoplasms / DNA Methylation / Gene Silencing / SOXF Transcription Factors / Wnt Signaling Pathway / Genetics / Hematopoietic System / Metabolism Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2016 Type: Article