Relationship Between Essential Tremor and Cerebellar Dysfunction According to Age
Journal of Clinical Neurology
;
: 76-80, 2005.
Article
in English
| WPRIM
| ID: wpr-27253
ABSTRACT
BACKGROUND:
The cerebellum and its neural circuitry have been assumed to play a major role in the pathophysiology of essential tremor (ET). In this study, we sought to find associations between ET and cerebellar dysfunction.METHODS:
We performed tandem gait test in 41 ET patients and 44 age-matched controls. Investigators assessed tandem gait by counting the number of missteps during ten-step tandem walk and each subject repeated the trial three times.RESULTS:
ET patients had a higher average and total numbers of missteps during tandem gait tests than control subjects (p or =70 years) showed significantly higher prevalence of tandem gait abnormality than young ones. Interaction terms determined by a likelihood ratio test was also statistically significant (p<0.05).CONCLUSIONS:
Dysfunction of cerebellar neural circuitry may be associated with the pathophysiological mechanism of ET. In addition, aging may be an important factor modifying the association.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Research Personnel
/
Aging
/
Odds Ratio
/
Cerebellar Diseases
/
Cerebellum
/
Prevalence
/
Essential Tremor
/
Gait
Type of study:
Etiology study
/
Prevalence study
Limits:
Humans
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2005
Type:
Article
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