Determination of tetrahydrofuran in urine by headspace solid-phase microextraction and gas chromatography / 中华劳动卫生职业病杂志

ABSTRACT

<p><b>OBJECTIVE</b>Headspace solid-phase microextraction (HS-SPME) was used pre-concentration procedure for the determination of tetrahydrofuran in urine by gas chromatography with hydrogen flame detector.</p><p><b>METHODS</b>Several parameters controlling SPME was studied and optimised SPME fiber, extraction time and extraction temperature, desorption time and desorption temperature.</p><p><b>RESULTS</b>Under optimal conditions, the correlation coefficient was 0.9998 and good recoveries (range from 93.0% ∼ 100.8%) were achieved, the detection limit was 0.5 µg/L.</p><p><b>CONCLUSION</b>The method can be applied to the determination of trace amount of tetrahydrofuran in urine.</p>