Virtual screening for components in Chicory combined with CNT2 target based on molecular docking / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3962-3967, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-272746
ABSTRACT
To virtual screen the compound of Chicory combined with the concentrative nucleoside transporter 2 (CNT2) in molecular docking technology.The homology model of hCNT2 was produced, and then the Vina software was employed to virtual screen the Chicory compound combined with CNT2. Compared with 7,8,3'-trihydroxyflavone, a CNT2 inhibitors, 23 score higher chicory compounds were hit.Meanwhile, the ten top compounds have been revealed that play important role in decrease the uric level. The bioactivity to CNT2 needs to be investigatedin experiment. CNT2 may be a potential target of chicory, which decreases the absorption of purine nucleoside in intestinal tract.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS