Investigation on inhibitory and apoptosis-inducing effects of saponins from Tribulus terrestris on hepatoma cell line BEL-7402 / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 681-684, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-272823
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the inhibitory and apoptosis-inducing effects of saponins from Tribulus terrestris (STT) on liver cancer cell line BEL-7402.</p><p><b>METHOD</b>MTT, SRB, Wright staining, acridine orange staining, flow cytometry, and Immunofluorescence microscopy were used to evaluate the effects of STT on BEL-7402 cell line.</p><p><b>RESULT</b>SMT had potent inhibitory effect on BEL-7402 cell line in a concentration-dependent manner. BEL-7402 cells exibited typical morphological alteration of apoptosis when sub-G1 peak could be seen. The expression of Bcl-2 was decreased in STT treated cells as compared with untreated control cells.</p><p><b>CONCLUSION</b>STT exerts its cytotoxic effect on BEL-7402 cells by inducing apoptosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Saponins
/
Drugs, Chinese Herbal
/
Chemistry
/
Apoptosis
/
Proto-Oncogene Proteins c-bcl-2
/
Tribulus
/
Cell Line, Tumor
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2004
Type:
Article
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