Your browser doesn't support javascript.
loading
Tolerability and toxicity of adjuvant cisplatin and gemcitabine for treating non-small cell lung cancer / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 2087-2091, 2013.
Article in English | WPRIM | ID: wpr-273032
ABSTRACT
<p><b>BACKGROUND</b>The combination of cisplatin and vinorelbine is an evidence-supported regimen for adjuvant chemotherapy for treating non-small cell lung cancer (NSCLC). But this doublet has considerable toxicity and unfavorable tolerability, and results in poor compliance. The cisplatin and gemcitabine regimen is one of the most active and well-tolerated regimens against advanced NSCLC, but its toxicity and tolerability has not been adequately evaluated in the adjuvant setting.</p><p><b>METHODS</b>From a lung cancer database we retrospectively reviewed NSCLC patients receiving adjuvant chemotherapy of cisplatin (75 mg/m(2)) and gemcitabine (1250 mg/m(2)) between January 2005 and December 2011. Postoperative demographics, compliance to adjuvant therapy and toxicity were retrieved from medical records.</p><p><b>RESULTS</b>A total of 132 patients met the criteria and were included in the study, 96 were male (72.7%) and 36 were female (27.3%). Median age was 60.5 years old, range 29 - 75 years, and 41.7% of patients were ≥ 65 years old. Overall, 68.2% patients received all four planned cycles, and the cumulative dose delivered for gemcitabine was 8333 mg (83.3% of the planned dose) and cisplatin 248 mg (82.7% of the planned dose). There were no treatment-related deaths. Grade 3/4 neutropenia developed in 47 patients (35.6%) and was the predominant hematologic toxicity. Common grade 3/4 non-hematologic toxicities were nausea/vomiting (22.0%), infection (12.3%), and febrile neutropenia (11.4%).</p><p><b>CONCLUSION</b>Cisplatin and gemcitabine are feasible for use in the adjuvant setting with a favorable toxicity profile and superior tolerability compared with published data on cisplatin and vinorelbine.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Antineoplastic Combined Chemotherapy Protocols / Retrospective Studies / Cisplatin / Carcinoma, Non-Small-Cell Lung / Therapeutic Uses / Deoxycytidine / Drug Therapy / Lung Neoplasms Type of study: Observational study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2013 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Antineoplastic Combined Chemotherapy Protocols / Retrospective Studies / Cisplatin / Carcinoma, Non-Small-Cell Lung / Therapeutic Uses / Deoxycytidine / Drug Therapy / Lung Neoplasms Type of study: Observational study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2013 Type: Article