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Expression of p21WAF1, p27KIP1 and cyclin E in ameloblastoma / 中华口腔医学杂志
Chinese Journal of Stomatology ; (12): 306-309, 2005.
Article in Chinese | WPRIM | ID: wpr-273230
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of cyclin E mRNA, p21(WAF1) mRNA and p27(KIP1) protein in human ameloblastoma (AB), and to explore the clinical and biological characteristics of AB.</p><p><b>METHODS</b>The expression of cyclin E mRNA, p21(WAF1) mRNA and p27(KIP1) protein in 54 cases of human AB were detected by in situ hybridization or immunohistochemistry (SP method).</p><p><b>RESULTS</b>The positive expression rate of cyclin E mRNA in the cytoplasm or cell nucleus of AB was 66.7% (36/54). The expression of cyclin E mRNA increased with AB recurrence and malignant transformation, and the difference of expression among primary AB, recurrent AB, and malignant AB, was statistically significant. The positive expression ratio of cyclin E mRNA in OKC was 50.0% (8/16). The p21(WAF1) mRNA expression in the cytoplasm or cell nucleus of AB decreased, and the positive ratio was 22.6% (12/54) in AB, 37.5% (6/16) in OKC, respectively. The p27(KIP1) protein expression in the cell nucleus of AB was positive in a small number of cases, and the positive rate was 16.7% (9/54) in AB, 6.3% (1/16) in OKC, respectively.</p><p><b>CONCLUSIONS</b>The genesis and invasion of AB is associated with the cell proliferation and differentiation, and regulated by the higher expression of cyclin E and the lower expression of p21(WAF1) and p27(KIP1).</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / RNA, Messenger / Ameloblastoma / Jaw Neoplasms / Oncogene Proteins / Cyclin E / Intracellular Signaling Peptides and Proteins / Cyclin-Dependent Kinase Inhibitor p21 / Cyclin-Dependent Kinase Inhibitor p27 / Genetics Limits: Adolescent / Adult / Aged / Child / Female / Humans Language: Chinese Journal: Chinese Journal of Stomatology Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / RNA, Messenger / Ameloblastoma / Jaw Neoplasms / Oncogene Proteins / Cyclin E / Intracellular Signaling Peptides and Proteins / Cyclin-Dependent Kinase Inhibitor p21 / Cyclin-Dependent Kinase Inhibitor p27 / Genetics Limits: Adolescent / Adult / Aged / Child / Female / Humans Language: Chinese Journal: Chinese Journal of Stomatology Year: 2005 Type: Article