Effect of buxu huayu qutan decoction on anti-oxidative capacity in aged patients with stable angina pectoris of coronary heart disease / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 695-697, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-273641
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the acting mechanism of Buxu Huayu Qutan Decoction (BHQD) for impacting the anti-oxidative capacity in aged patients with stable angina pectoris of coronary heart disease (AP-CHD).</p><p><b>METHODS</b>Forty patients of AP-CHD, Chinese medicine diagnosed as Xiong-bi, were equally assigned to the treatment group and the control group. Superoxide dismutase (SOD) activity and lipid peroxide (LPO) contents in blood, and mRNA expression of manganese-containing superoxide dismutase (MnSOD) in peripheral mononuclear cells were determined before and after treatment by biochemical and molecular biologic techniques.</p><p><b>RESULTS</b>No significant change of plasma SOD and LPO was found in the control group after treatment (P >0.05), while the plasma SOD activity increased and LPO content lowered in the treatment group significantly (P<0.01). Moreover, mRNA expression of MnSOD in the treatment group after treatment was obviously higher than that in the control group (P <0.01).</p><p><b>CONCLUSIONS</b>The acting mechanism of BHQD for AP-CHD treatment might partially due to its effects in inducing gene expression of MnSOD in mononuclear cells, enhancing SOD activity, decreasing LPO content, maintaining oxidation/antioxidation equilibrium in myocardial cells, blocking the chain reaction of lipid peroxidation, intervening the production and enhancing the scavenging of oxygen free radicals.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Superoxide Dismutase
/
Blood
/
Drugs, Chinese Herbal
/
Lipid Peroxidation
/
Oxidative Stress
/
Coronary Disease
/
Therapeutic Uses
/
Drug Therapy
/
Angina Pectoris
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2009
Type:
Article
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