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Evaluation of PFA P2Y assay in monitoring platelet function in elderly patients with cardiovascular disease receiving clopidogrel treatment / 南方医科大学学报
Journal of Southern Medical University ; (12): 533-536, 2016.
Article in Chinese | WPRIM | ID: wpr-273729
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the value of a new platelet function test PFA P2Y (PFA-200) in monitoring clopidogrel treatment for cardiovascular disease in elderly patients.</p><p><b>METHODS</b>Fifty-six elderly patients receiving clopidogrel therapy in the Department of Cardiology of General Hospital of PLA from March to August in 2016 and 85 healthy volunteers were recruited for analysis. All the subjects underwent PFA P2Y, LTA (light transmittance aggregometry) and TEG (Thromboelastograph) tests, and Spearman correlation coefficients were used to test the associations between test results. The agreement among the 3 platelet function test methods was assessed using Cohen's kappa coefficient.</p><p><b>RESULTS</b>Correlation coefficient (r) was -0.701 (P<0.001) between PFA P2Y and LTA, and 0.475 (P<0.001) between PFA P2Y and TEG. The agreement was 75% between PFA P2Y and LTA and 67.9% between PFA P2Y and TEG. The κ value was 0.434 (P=0.001) between PFA P2Y and LTA and 0.242 (P=0.046) between PFA P2Y and TEG. With ADP-induced maximum platelet aggregation rate of LTA >50% as the laboratory clopidogrel resistance, the cut-off value of PFA P2Y was 119 s (AUC=0.733) with a sensitivity of 75.6% and a specificity of 73.3%.</p><p><b>CONCLUSION</b>PFA P2Y has a moderate correlation and agreement with LTA, but has a poor correlation and agreement with TEG. PFA P2Y can be useful for assessing the effects of clopidogrel therapy and the association of the cut-off value (119 s) with the long-term clinical ischemic events needs be confirmed in further study.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Platelet Function Tests / Biological Assay / Blood Coagulation Tests / Blood Platelets / Ticlopidine / Platelet Aggregation Inhibitors / Cardiovascular Diseases / Platelet Aggregation / Sensitivity and Specificity / Therapeutic Uses Type of study: Diagnostic study Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Platelet Function Tests / Biological Assay / Blood Coagulation Tests / Blood Platelets / Ticlopidine / Platelet Aggregation Inhibitors / Cardiovascular Diseases / Platelet Aggregation / Sensitivity and Specificity / Therapeutic Uses Type of study: Diagnostic study Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2016 Type: Article