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Coexpression of MAP2K4 and vimentin proteins in human endometrial carcinoma and its clinicopathological significance / 南方医科大学学报
Journal of Southern Medical University ; (12): 157-164, 2016.
Article in Chinese | WPRIM | ID: wpr-273794
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the expression of MAP2K4 and vimentin in human endometrial carcinoma (EC) and their association with the clinicopathological features and prognosis of the patients.</p><p><b>METHODS</b>MAP2K4 and vimentin expressions were detected immunohistochemically in paraffin-embedded tissue sections from 128 patients with EC, and the correlation of MAP2K4 and vimentin expressions with the clinicopathological factors of the patients was analyzed.</p><p><b>RESULTS</b>MAP2K4 and vimentin proteins were positively expressed in 49 (38.3%) and 83 (64.8%) of the patients, respectively. A positive expression of MAP2K4 was negatively correlated with FIGO stage of the tumor (P=0.010) and lymph node status (P=0.016); a positive expression of vimentin was positively correlated with FIGO stage of the tumor (P=0.025), histological grades (P=0.017), depth of myometrial invasion (P=0.044) and lymph node status (P=0.032). MAP2K4 was inversely associated with vimentin expression in EC(r=-0.598, P<0.001). Patients positive for MAP2K4 tended to have a higher overall survival rate (P=0.002), and those positive for vimentin tended to have a lower overall survival rate (P=0.007); patients positive for MAP2K4 but negative for vimentin had the longest survival time, while those negative for MAP2K4 and positive for vimentin had lowest survival rate (P=0.004).</p><p><b>CONCLUSION</b>Detection of MAP2K4 and vimentin might help in early diagnosis and prognostic evaluation of patients with EC.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Vimentin / Survival Rate / Endometrial Neoplasms / MAP Kinase Kinase 4 / Metabolism Type of study: Prognostic study / Screening study Limits: Female / Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Vimentin / Survival Rate / Endometrial Neoplasms / MAP Kinase Kinase 4 / Metabolism Type of study: Prognostic study / Screening study Limits: Female / Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2016 Type: Article