Efficacy of early continuous hyperthermic peritoneal perfusion on patients with advanced gastric carcinoma after surgical resection / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 448-450, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-273816
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of early continuous hyperthermic peritoneal perfusion (CHPP) on patients of advanced gastric carcinoma after surgical resection.</p><p><b>METHODS</b>Seventy patients were divided into control and treatment group. Patients in treatment group received CHPP 1 or 2 days postoperatively. Treatment was administered daily consecutively for 4 days. Patients in control group underwent resection of gastric carcinoma without CHPP. Chemotherapy was administered of Calcium Folinate and 5-Fluorouracil (LF regimen) intravenously for 6 cycles in both groups two or three weeks postoperatively. Survival and recurrence in both groups were observed and compared.</p><p><b>RESULTS</b>One-year survival and recurrence rates were 83.3% and 8.3% in treatment group, 79.4% and 11.7% in control group, there were no significant differences between the two groups. Three-year survival and recurrence rates were 63.9% and 19.4 in treatment group, 39.8% and 44.1% in control group, there were significant differences between the two groups.</p><p><b>CONCLUSION</b>Early administration of CHPP to patients with advanced gastric carcinoma after surgery may be advantageous for preventing peritoneal metastasis and recurrence, thus may prolong survival time.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Perfusion
/
Postoperative Period
/
Stomach Neoplasms
/
Chemotherapy, Cancer, Regional Perfusion
/
Treatment Outcome
/
Drug Therapy
/
Hyperthermia, Induced
/
Neoplasm Staging
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2008
Type:
Article
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