The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus
Journal of Periodontal & Implant Science
;
: 33-38, 2010.
Article
in English
| WPRIM
| ID: wpr-27385
ABSTRACT
PURPOSE:
The purpose of this study was to observe and quantify the expression of interleukin-4 (IL-4), interferon-gamma (IFN-gamma), and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in the gingival tissue of patients with type 2 diabetes mellitus (DM) and healthy adults with chronic periodontitis.METHODS:
Twelve patients with type 2 DM and chronic periodontitis (Group 3), twelve patients with chronic periodontitis (Group 2), and twelve healthy individuals (Group 1) were included in the study. Clinical criteria of gingival (sulcus bleeding index value, probing depths) and radiographic evidences of bone resorption were divided into three groups. The concentrations of cytokines were determined by a western blot analysis and compared using one-way ANOVA followed by Tukey's test.RESULTS:
The expression levels of IFN-gamma and TIMP-2 showed an increasing tendency in Groups 2 and 3 when compared to Group 1. On the other hand, the expression of IL-4 was highest in Group 1.CONCLUSIONS:
The findings suggest that IFN-gamma and TIMP-2 may be involved in the periodontal inflammation associated with type 2 DM. IL-4 may be involved in the retrogression of the periodontal inflammation associated with type 2 DM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone Resorption
/
Blotting, Western
/
Cytokines
/
Interleukin-4
/
Interferon-gamma
/
Tissue Inhibitor of Metalloproteinases
/
Tissue Inhibitor of Metalloproteinase-2
/
Matrix Metalloproteinase 2
/
Diabetes Mellitus, Type 2
/
Chronic Periodontitis
Limits:
Adult
/
Humans
Language:
English
Journal:
Journal of Periodontal & Implant Science
Year:
2010
Type:
Article
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