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Expression of N-Cadherin in Patients with Multiple Myeloma and Its Clinical Significance / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1044-1048, 2015.
Article in Chinese | WPRIM | ID: wpr-274096
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of N-Cadherin in the patients with multiple myeloma (MM) and to explore its clinical significance.</p><p><b>METHODS</b>A total of 64 patients with multiple myeloma were enrolled in this study. The expression of N-Cadherin in bone marrow CD38⁺/CD138⁺ cells from multiple myeloma patients was detected by flow cytometry. The relationship between N-Cadherin expression and clinical prognostic factors was analyzed.</p><p><b>RESULTS</b>Among 64 cases of MM, the expression of N-Cadherin in 17 patients (26.56%) was high (> 20%), while that in 47 cases (73.44%) was low (< 20%); The differences of N-Cadherin expression in disease staging and classification, known prognostic factors, myeloma cell antigen expression and bone damage between patients with high and low N-Cadherin expression were not statistically different; the difference N-Cadherin expression in genetic abnormalities such as D13S319 deletion, RB1 deletion and IGH gene rearrangement between above-methioned two groups was not significant. The 1q21 amplification rate in the group with high expression of N-Cadherin was enhanced significently; the overall survival (OS) times of patients with abnormally high and low expression levels of N-Cadherin were 26.7 months and 55.5 months respectively, and the difference was statistically significant (P < 0.05).</p><p><b>CONCLUSION</b>The high expression of N-Cadherin in multiple myeloma may be one of the indicator for poor prognosis of MM, which may be related with 1q21 amplification.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone and Bones / Bone Marrow / Cadherins / Flow Cytometry / Multiple Myeloma Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone and Bones / Bone Marrow / Cadherins / Flow Cytometry / Multiple Myeloma Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2015 Type: Article