Comparison of two regimens of vitamin D supplementation for vitamin D-deficient neonates
Singapore medical journal
;
: 266-270, 2014.
Article
in English
| WPRIM
| ID: wpr-274239
ABSTRACT
<p><b>INTRODUCTION</b>Vitamin D deficiency is common in pregnant women, and supplementation of vitamin D is necessary for the infants of these women. This study explored the efficacy of an alternative way of vitamin D supplementation in an area with a high prevalence of vitamin D deficiency in mothers.</p><p><b>METHODS</b>This was a non-randomised clinical trial conducted in 2010 in Yazd, Iran. Full-term healthy infants born to vitamin D-deficient mothers (n = 82) were divided into the high-dose regimen (HDR; single oral bolus 30,000 IU vitamin D3, n = 34) and the standard-dose regimen (SDR; 400 IU/day vitamin D3 within two weeks of life, n = 48) groups. 25-hydroxyvitamin D (25OHD) was measured using chemiluminescent immunoassays, and 25OHD level > 20 ng/mL was deemed sufficient.</p><p><b>RESULTS</b>Over 90% of infants in the HDR group attained vitamin D sufficiency within one month, while comparable sufficiency was reached in the SDR group only after four months. At two months, the proportion of infants attaining 25OHD > 30 ng/mL was 93.3% and 27.9% in the HDR and SDR groups, respectively (p = 0.003). None of our infants achieved 25OHD levels > 100 ng/mL.</p><p><b>CONCLUSION</b>For infants born to vitamin D-deficient mothers, oral supplementation of 30,000 IU vitamin D3 during the first month of life, followed by a routine recommended dose of 400 IU/day, should be considered. The four-month lag for attaining vitamin D sufficiency in 90% of infants in the SDR group may have clinical implications and should be further investigated.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Time Factors
/
Vitamin D
/
Vitamin D Deficiency
/
Immunoassay
/
Prevalence
/
Treatment Outcome
/
Dietary Supplements
/
Therapeutic Uses
/
Luminescence
/
Drug Therapy
Type of study:
Controlled clinical trial
/
Prevalence study
Limits:
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
/
Pregnancy
Country/Region as subject:
Asia
Language:
English
Journal:
Singapore medical journal
Year:
2014
Type:
Article
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