Comparative study on pharmacokinetics of six major alkaloids in Zuojin Wan microemulsion based gel and hydrogel / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3327-3331, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-274375
ABSTRACT
<p><b>OBJECTIVE</b>To compare the pharmcoknetic parameters of six major alkaloids in the two drug delivery system of Zuojin Wan, by LC-MS assaying the six major alkaloids plasma concentration.</p><p><b>METHOD</b>The blood samples were collected at different time after transdermal administration. The plasma concentration of six major alkaloids were detected by LC-MS, then the concentration-time data are modulated by software WinNonlin.</p><p><b>RESULT</b>Took the six alkaloids (berberine palmatine coptisine jateorhizine evodiamine rutecarpine) as index components, the relative bioavailability were 131%, 127%, 108%, 121%, 92%, 109%, respectively, the ratio of Ka were 10.5, 5.1, 3.7, 0.8, 1.8, 1.5, respectively.</p><p><b>CONCLUSION</b>The LC-MS can be applied in the determination of six major alkaloids plasma concentration. The pharmcoknetic parameters indicated that Zuojin Wan microemulsion gel delivery system can accelerate the transdermal absorption rate of Zuojin Wan, compared with the hydrogel drug delivery system.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mass Spectrometry
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Chemistry
/
Chromatography, Liquid
/
Drug Delivery Systems
/
Hydrogels
/
Alkaloids
/
Emulsions
/
Gels
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article
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