Advances in researches on genetic predisposition to steroid-induced osteonecrosis of the femoral head / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 156-159, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-274457
ABSTRACT
The pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH) is not very clear at present. For the past few years researches showed that the SONFH related to genetic predisposing factors. The related research progresses were reviewed in this article to show the correlation between genetic mutation and genetic polymorphism of steroid metabolism and transport, resistance and receptor, coagulation and fibrinolysis, lipid and bone metabolism and susceptibility to SONFH. The article also discussed current problems, countermeasure and future applications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Receptors, Glucocorticoid
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
/
ATP Binding Cassette Transporter, Subfamily B
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Cytochrome P-450 CYP3A
/
Lipid Metabolism
/
Femur Head Necrosis
/
Genetics
/
Glucocorticoids
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Orthopaedics and Traumatology
Year:
2010
Type:
Article
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