Expression of mammary serine proteinase inhibitor in oral squamous cell carcinoma and its clinical significance / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression of mammary serine proteinase inhibitor(Maspin) in patients with oral squamous cell carcinoma and its relationship with clinicopathological features.</p><p><b>METHODS</b>The Maspin protein expression was examined in 45 patients with oral squamous cell carcinoma and in non-malignant oral epithelia by immunohistochemical staining. The relationship between the Maspin protein expression and the clinicopathological parameters was statistically analyzed.</p><p><b>RESULTS</b>The Maspin protein expression in the cancerous tissues of oral squamous cell carcinoma was lower than that in the non-malignant oral epithelia (P = 0.001). Negative correlation was found between the Maspin protein expression in cancerous tissue and the status of lymph node metastasis (P = 0.038). Positive Maspin protein expression indicated negative lymph node metastasis, and negative correlation was also found between the Maspin protein expression and the postoperative metastasis (P = 0.004). Positive correlation was found between the Maspin expression and the patients' survival rate (P = 0.014), patients with positive Maspin protein expression having higher survival rate than those with negative Maspin expression.</p><p><b>CONCLUSIONS</b>Maspin might be useful as a potential prognostic marker for oral squamous cell carcinoma.</p>