Progress in the fragment-based drug discovery / 药学学报
Acta Pharmaceutica Sinica
;
(12): 14-24, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-274596
ABSTRACT
As an extension of the structure-based drug discovery, fragment-based drug discovery is matured increasingly, and plays an important role in drug development. Fragments in a small library, with lower molecular mass and high "ligand efficiency", are detected by SPR, MS, NMR, X-ray crystallography technologies and other biophysical methods. Then they are considered as starting points for chemical optimization with the guidance of structural biology methods to get good "drug-like" lead and candidate compounds. In this article, we reviewed the current progress of fragment-based drug discovery and detailed a number of examples to illustrate the novel strategies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptide Fragments
/
Protein Conformation
/
Magnetic Resonance Spectroscopy
/
Chemistry
/
Computer-Aided Design
/
Crystallography, X-Ray
/
Surface Plasmon Resonance
/
Small Molecule Libraries
/
Drug Discovery
/
Ligands
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS