Identification of metabolites of arbidol by ultra-high performance liquid chromatography tandem mass spectrometry / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1521-1526, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-274628
ABSTRACT
UPLC-MS-MS system was used for the identification of arbidol metabolites in the rat feces, urine and plasma samples. The system was so powerful a way with high ability of separation and analysis, based on both chromatography and mass properties. The isotope of Br was also a good indicator for metabolites finding. There were altogether 9 metabolites detected and identified, including 2 phase I biotransformation products and 7 phase II ones. It is concluded that arbidol mainly undergo metabolic reactions such as N-demethylation, S-oxidation, glucuronidation and sulfation in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urine
/
Blood
/
Pharmacokinetics
/
Biotransformation
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Rats, Wistar
/
Tandem Mass Spectrometry
/
Feces
/
Indoles
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS