TREK1 potassium channels and depression / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1403-1408, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-274646
ABSTRACT
Major depression disorder is an increasing heavy burden in modem society, but its pathological mechanism is still vague. Recent evidence indicated that two pore potassium channel, TREK1, is one of the important drug targets of antidepressants. The structural and functional research progress of TREK1 potassium channel were reviewed with an emphasis on its roles in anti-depression, neuronal protection, and neuronal plasticity. The complicated interactions between TREK1 potassium channel and monoamine transmitters-receptors were also reviewed and future directions to explore the underline mechanism were also discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Polymorphism, Genetic
/
Serotonin
/
Receptors, Serotonin
/
Drug Delivery Systems
/
Potassium Channels, Tandem Pore Domain
/
Receptors, Serotonin, 5-HT4
/
Depressive Disorder, Major
/
Gene Knockout Techniques
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
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