Synthesis and biological evaluation of noscapine analogues as microtubule-interfering agents / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1347-1357, 2012.
Article
in English
| WPRIM
| ID: wpr-274655
ABSTRACT
A series of noscapine analogues have been synthesized via 13-step reaction starting from 2-hydroxy-3-methoxybenzaldehyde. Anti-tumor activities of these compounds were evaluated against HL-60 cell lines in vitro by the standard MTT assay. It was found that most of these derivatives showed appreciable inhibitory activity against HL-60 and tubulin polymerization. The results also indicated that the potency of compound 31 is about three times more than that ofnoscapine against HL-60 cell line and tubulin polymerization. Moreover, it induced a massive accumulation of cells in G2/M phase. These results showed noscapine and its derivatives were worth to be intensively studied further.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Tubulin
/
Cell Cycle
/
HL-60 Cells
/
Tubulin Modulators
/
Polymerization
/
Metabolism
/
Antineoplastic Agents
/
Noscapine
Limits:
Humans
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS