Advances in the study of natural small molecular antibody / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1281-1286, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-274664
ABSTRACT
Small molecule antibodies are naturally existed and well functioned but not structurally related to the conventional antibodies. They are only composed of heavy protein chains or light chains, much smaller than common antibody. The first small molecule antibody, called Nanobody was engineered from heavy-chain antibodies found in camelids. Cartilaginous fishes also have heavy-chain antibodies (IgNAR, "immunoglobulin new antigen receptor"), from which single-domain antibodies called Vnar fragments can be obtained. In addition, free light chain (FLC) antibodies in human bodies are being developed as therapeutic and diagnostic agents. Comparing to intact antibodies, common advantages of small molecule antibodies are with better solubility, tissue penetration, stability towards heat and enzymes, and comparatively low production costs. This article reviews the structural characteristics and mechanism of action of the Nanobody, IgNAR and FLC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sharks
/
Camelids, New World
/
Receptors, Antigen
/
Chemistry
/
Immunoglobulin Light Chains
/
Therapeutic Uses
/
Allergy and Immunology
/
Single-Chain Antibodies
/
Single-Domain Antibodies
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
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