Solubility behavior of four diastereomeric salts and two amino acids in near-critical CO2 / 药学学报
Acta Pharmaceutica Sinica
;
(12): 355-358, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-274811
ABSTRACT
<p><b>AIM</b>To establish a suitable condition for extraction of phenylalanine (Phe), 5-hydroxytryptophan (5-OH-Trp) and four diastereomeric salts, (1R,2S)-ephedrine- (2S,3S)-tartaric acid, (1R,2S)-ephedrine-(2R,3R)-tartaric acid, (1S,2S)-pseudoephedrine-(2S,3S)-tartaric acid, (1S,2S)-pseudoephedrine- (2R,3R)-tartaric acid in supercritical fluid extraction and to assess the solubilities of Phe, 5-OH-Trp and the four diastereomeric salts in CO2.</p><p><b>METHODS</b>Single-pass method and HPCE.</p><p><b>RESULTS</b>The solubilities of Phe, 5-OH-Trp and the four diastereomeric salts in CO2 were determined over temperature and pressure ranges of 25-50 degrees C and 6.32-34.03 MPa respectively. The experimental results showed that the solubilities of Phe, 5-OH-Trp and the four diastereomeric salts do not increase with density of CO2. There existed a maximum in the critical region of CO2.</p><p><b>CONCLUSION</b>The dramatically high solubilities in the pressure of 6.32-7.78 MPa show a critical behavior, which can be explained by critical characteristic through thermodynamics analysis. The results suggest that the separation of Phe, 5-OH-Trp and the four diastereomeric salts is more efficient in critical region of CO2.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenylalanine
/
Pressure
/
Solubility
/
Stereoisomerism
/
Tartrates
/
Temperature
/
Chemistry
/
5-Hydroxytryptophan
/
Ephedrine
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2002
Type:
Article
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