In vitro drug release profiles and mucoadhesive property of bioadhesive microspheres of metronidazole / 药学学报
Acta Pharmaceutica Sinica
;
(12): 226-228, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-274862
ABSTRACT
<p><b>AIM</b>To prepare bioadhesive microspheres of metronidazole (Metro) with prolonging resident time in the stomach and sustaining drug release.</p><p><b>METHODS</b>The microspheres were prepared by a drying-in-liquid method. The appearance, particle size and drug release in vitro were examined. The factors influencing bioadhesive property and drug release, such as ethyl cellulose (EC)/carbopol 934P (CP) ratio, particle size and Metro content were investigated.</p><p><b>RESULTS</b>The average diameter of the Metro-EC-CP microspheres was 559.9 microns. The release profiles of metronidazole were shown to fit to first-order equations well. With the increase of CP content in the Metro-EC-CP microspheres, the microspheres showed better mucoadhesion and faster drug release. The drug release rate decreased with the increase of particle size and the decrease of Metro content.</p><p><b>CONCLUSION</b>The Metro-EC-CP microspheres have a sound mucoadhsive property and sustained drug release when the ratio of EC and CP was 173 and Metro content was 25%. The drug release was shown to last for 8 h in 0.1 mol.L-1 hydrochloric acid.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Acrylates
/
Cell Adhesion
/
Chemistry
/
Rats, Sprague-Dawley
/
Delayed-Action Preparations
/
Fluorocarbons
/
Gastric Mucosa
/
Metronidazole
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2002
Type:
Article
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