Analysis of quality of life in elderly patients with coronary artery disease after drug-eluting stent implantation / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To compare the change of quality of life (QOL) between elderly (≥ 65 years) and non-elderly (< 65 years) coronary artery disease (CAD) patients after drug-eluting stents (DES) implantation.</p><p><b>METHODS</b>Patients with CAD treated with DES between March 2009 and January 2010 were enrolled. All patients were prospectively interviewed at baseline and 6-month after DES implantation. Changes of overall health perception between the elderly and non-elderly patients were compared by using validated questionnaire (SF-36 health survey).</p><p><b>RESULTS</b>Scores for physical component summary (PCS) and mental component summary (MCS) were significantly worse in elderly patients than in non-elderly patients both at baseline and 6 months after DES implantation (baseline 45.3 ± 16.2 vs. 55.6 ± 22.2, 61.7 ± 21.5 vs. 65.6 ± 17.9; 6-month 55.4 ± 19.9 vs. 66.7 ± 18.1, 65.9 ± 19.8 vs. 73.6 ± 16.8, all P < 0.05). QOL improved significantly after DES implantation for all eight scales and PCS as well as MCS in both age groups (all P < 0.01). The change of PCS score was similar between the two age groups (10.92 ± 7.62 vs. 10.53 ± 6.81, P = 0.43). Physiological function [22.11 (10.28 to 41.49) vs. 11.13 (-0.23 to 19.65), P < 0.01] improvement was better but the change of physical function, body pain and general health [6.65 ± 2.45 vs. 7.65 ± 2.16, 10.61 (4.38 - 14.47) vs. 21.20 (11.81 to 31.14), 2.10 (-2.30 to 5.70) vs. 4.72 (2.28 to 6.74), all P < 0.01] were worse in elderly patients than in non-elderly group. The improvement of MCS in non-elderly group was superior to elderly group [6.43 (3.11 to 8.70) vs. 5.52 (-1.01 to 9.33), P < 0.01] exampled by social function [8.14 (3.53 to 14.03) vs. 1.74 (-1.73 to 6.79)] and mental health score [1.26 (0.61 to 7.15) vs. 0.81 (0.59 to 7.18), all P < 0.01].</p><p><b>CONCLUSION</b>QOL is significantly improved in both elderly and non-elderly CAD patients after DES implantation. Improvement in physical health is similar between the two age groups, but the improvement of mental health is more significant in non-elderly patients than in elderly CAD patients.</p>