Human Epidermal Growth Factor Receptor 2 Expression in Unresectable Gastric Cancers: Relationship with CT Characteristics
Korean Journal of Radiology
;
: 809-820, 2017.
Article
in English
| WPRIM
| ID: wpr-27517
ABSTRACT
OBJECTIVE:
To retrospectively analyze the qualitative CT features that correlate with human epidermal growth factor receptor 2 (HER2)-expression in pathologically-proven gastric cancers. MATERIALS ANDMETHODS:
A total of 181 patients with pathologically-proven unresectable gastric cancers with HER2-expression (HER2-positive [n = 32] and negative [n = 149]) were included. CT features of primary gastric and metastatic tumors were reviewed. The prevalence of each CT finding was compared in both groups. Thereafter, binary logistic regression determined the most significant differential CT features. Clinical outcomes were compared using Kaplan-Meier method.RESULTS:
HER2-postive cancers showed lower clinical T stage (21.9% vs. 8.1%; p = 0.015), hyperattenuation on portal phase (62.5% vs. 30.9%; p = 0.003), and was more frequently metastasized to the liver (62.5% vs. 32.2%; p = 0.001), than HER2-negative cancers. On binary regression analysis, hyperattenuation of the tumor (odds ratio [OR], 4.68; p < 0.001) and hepatic metastasis (OR, 4.43; p = 0.001) were significant independent factors that predict HER2-positive cancers. Median survival of HER2-positive cancers (13.7 months) was significantly longer than HER2-negative cancers (9.6 months) (p = 0.035).CONCLUSION:
HER2-positive gastric cancers show less-advanced T stage, hyperattenuation on the portal phase, and frequently metastasize to the liver, as compared to HER2-negative cancers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach
/
Stomach Neoplasms
/
Logistic Models
/
Prevalence
/
Retrospective Studies
/
Epidermal Growth Factor
/
ErbB Receptors
/
Liver
/
Methods
/
Neoplasm Metastasis
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Qualitative research
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Korean Journal of Radiology
Year:
2017
Type:
Article
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