Pharmacokinetics and tissue distribution of α-hederin sodium salt in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2543-2548, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-275208
ABSTRACT
To study the pharmacokinetics and tissue distribution characteristics of α-hederin sodium salt in rats. 100 mg•kg⁻¹ α-hederin sodium salt was given to the rats by intragastric administration, and LC-MS/MS method was used to determine its concentration at different time in plasma and tissues. Plasma and tissue samples were treated with methanol protein deposition method. Main pharmacokinetic parameters were as follows: tmax (0.97±1.23) h, Cmax (222.53±57.28) μg•L⁻¹, AUC0-t (1 262±788.9) h•μg•L⁻¹, T1/2 (17.94±9.50) h. α-hederin can be detected in heart, liver, spleen, lung, kidney, brain, muscle and adipose. The results showed that α-hederin sodium salt was absorbed fast and eliminated slowly in rats after oral administration. It was widely distributed in body tissues and livers kept the highest concentrations among various tissues at different time, so it can be speculated that α-hederin may have certain targeting property on livers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2016
Type:
Article
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