In vivo pro- and anti-inflammatory cytokines in normal and patients with rheumatoid arthritis
Annals of the Academy of Medicine, Singapore
; : 96-99, 2007.
Article
in En
| WPRIM
| ID: wpr-275224
Responsible library:
WPRO
ABSTRACT
<p><b>INTRODUCTION</b>Rheumatoid arthritis (RA) is a chronic, deforming arthritis that can lead to disabilities and poor quality of life. Cytokines are protein mediators of inflammation and are produced as a result of the activation of various cellular reactions. They are the final mediators and/or regulators of the inflammatory process.</p><p><b>MATERIALS AND METHODS</b>The sera from 64 RA patients were assayed for both Th-1 and Th-2 related cytokines and soluble TNF-alpha receptors (IFN-gamma, TGF-beta, TNF-alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, sTNF-R1 and sTNFR2) using ELISA.</p><p><b>RESULTS</b>The pro-inflammatory cytokines (IL-1, IL-6, IL-8, IL-18 and TNF- alpha) were significantly elevated in RA patients, while TGF-beta, an immunomodulatory cytokine, was elevated in control individuals. When the RA patients were categorised as active or inactive based on DAS scores, similar cytokines profiles were observed in both RA sub-groups. However, assays of sTNF-R1 and sTNFR-2 were noted to be significantly elevated in inactive RA patients when compared to active patients.</p><p><b>CONCLUSION</b>Our findings indicate that local production of cytokine inhibitors is capable of diminishing disease activity and cytokine activity.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Arthritis, Rheumatoid
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Blood
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Cell Differentiation
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Chemistry
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Cytokines
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Transforming Growth Factor beta
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Receptors, Tumor Necrosis Factor, Type I
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Receptors, Tumor Necrosis Factor, Type II
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
En
Journal:
Annals of the Academy of Medicine, Singapore
Year:
2007
Type:
Article