Recombinant tissue plasminogen activator (r-TPA) in fibrin dissolution due to postoperative endophthalmitis

ABSTRACT

<p><b>INTRODUCTION</b>The aim of this paper was to describe the use of r-TPA for fibrin clot dissolution following endophthalmitis.</p><p><b>CLINICAL PICTURE</b>A 74-year-old man presented with painful loss of vision following routine uncomplicated cataract surgery.</p><p><b>TREATMENT</b>He underwent standard treatment for postoperative endophthalmitis but despite this, developed a dense fibrin clot. He underwent further intracameral injection of r-TPA.</p><p><b>OUTCOME</b>Following the injection, he had complete clot dissolution within 2 hours without any complications.</p><p><b>CONCLUSION</b>R-TPA may be used effectively in the treatment of fibrin clots secondary to endophthalmitis following cataract surgery.</p>