Relationship between tic symptom severity and amplitude of low frequency fluctuation of resting-state functional magnetic resonance imaging of Tourette syndrome / 中华儿科杂志
Chinese Journal of Pediatrics
;
(12): 448-452, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-275690
ABSTRACT
<p><b>OBJECTIVE</b>To examine the relationship between tic symptom severity and amplitude of low frequency fluctuation (ALFF) brain functioning of the first-episode Tourette syndrome through resting-state functional magnetic resonance imaging (fMRI).</p><p><b>METHOD</b>Sixteen subjects were all recruited from the outpatient department of pediatrics, Beijing Anding Hospital, Capital Medical University and were all first-episode Tourette syndrome patients [male 13, female 3; age 6-16 years; mean age (11.00 ± 2.92) years]; mean education time (5.06 ± 2.86) years; course 14-104 months; mean (48.44 ± 25.00) months; scores of YGTSS at baseline tic severity score 37.88 ± 5.39; global damage score 25.63 ± 12.63. All the subjects experienced resting-state fMRI scans and ALFF were calculated in three frequency ranges 0.01-0.1 Hz, 0.01-0.027 Hz and 0.027-0.073 Hz. First-episode Tourette syndrome patients and 16 gender, age, and education-matched normal controls experienced resting-state fMRI scans. Correlation analysis was performed in between the amplitude of low frequency fluctuation (ALFF) and the severity of tic symptom. P < 0.05 and k value ≥ 10 were considered to be of significance.</p><p><b>RESULT</b>In tic symptom patients, tic severity (total tic scores of YGTSS) was positively correlated with the ALFF values in the orbital part of left superior frontal gyrus (0.01-0.1 Hzr = 0.83,0.027-0.073 Hzr = 0.91, P < 0.05, respectively), right middle frontal gyrus (0.01-0.027 Hzr = 0.85,0.027-0.073 Hzr = 0.57, P < 0.05, respectively ) and orbital part of left middle frontal gyrus (0.01-0.027 Hzr = 0.64, P < 0.05). Tic severity was negatively correlated with the ALFF values in the right calcarine fissure and surrounding cortex (0.01-0.1 Hzr = -0.65,0.01-0.027 Hzr = -0.69, P < 0.05, respectively ) and the left calcarine fissure and surrounding cortex (0.027-0.073 Hzr = -0.81, P < 0.05).</p><p><b>CONCLUSION</b>Tic symptom severity of the first-episode Tourette syndrome is associated with abnormal brain activity patterns of specific brain areas.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parietal Lobe
/
Pathology
/
Rest
/
Tic Disorders
/
Severity of Illness Index
/
Brain
/
Magnetic Resonance Imaging
/
Tourette Syndrome
/
Case-Control Studies
/
Cerebral Cortex
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pediatrics
Year:
2013
Type:
Article
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