Expression of soluble human triggering receptors on myeloid cell-1 in patients with multiple trauma and its clinical significance / 中华外科杂志
Chinese Journal of Surgery
;
(12): 51-53, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-275900
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression profile of human soluble triggering receptor on myeloid cell-1 (sTREM-1) in patients with multiple trauma and determine its clinical significance.</p><p><b>METHODS</b>Peripheral blood of 52 patients admitted to the hospital from October 2007 to January 2008 with multiple traumas with injury severity score (ISS) > or = 16 and 7 healthy volunteers were obtained, and sera samples were isolated. sTREM-1 was determined by semi-quantitative immunoblot technique. TNF-alpha and C-reactive protein (CRP) were determined by ELISA.</p><p><b>RESULTS</b>sTREM-1 of patients with multiple traumas was significantly increased as compared with that of control (P < 0.001), and sTREM-1 of ISS > or = 25 group was significantly higher than that of 16 < or = ISS < 25 group (P < 0.05). sTREM-1 level correlated closely with TNF-alpha level (r = 0.845, P < 0.05), but did not correlate with CRP (r = 0.426, P > 0.05). In patients with sepsis, sTREM-1 on 1, 2 and 7 d was (25.1 +/- 2.2), (31.9 +/- 2.6) and (25.2 +/- 1.9) ng/L, respectively. In patients without sepsis, sTREM-1 on 1, 2 and 7 d was (15.8 +/- 1.3), (24.2 +/- 2.0) and (13.9 +/- 1.5) ng/L, respectively. sTREM-1 of patients with sepsis was significantly higher than that of patients without sepsis (P < 0.05).</p><p><b>CONCLUSIONS</b>Serum sTREM-1 correlates closely with ISS, TNF-alpha and onset of sepsis, indicating that it may play an important role in the development of sepsis in patients with multiple traumas.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
C-Reactive Protein
/
Membrane Glycoproteins
/
Multiple Trauma
/
Receptors, Immunologic
/
Tumor Necrosis Factor-alpha
/
Sepsis
/
Myeloid Cells
/
Allergy and Immunology
/
Triggering Receptor Expressed on Myeloid Cells-1
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2009
Type:
Article
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