Early diagnosis of prostate cancer by combined use of Trp-p8 expression and PSA density of the transition zone / 中华男科学杂志
National Journal of Andrology
;
(12): 724-728, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-276029
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of the Trp-p8 protein in the prostate tissue of the PSA "grey zone" with different PSA density of the transition zone (PSADTZ) and explore the value of determining Trp-p8 expression and PSADTZ in the early diagnosis of prostate cancer (PCa).</p><p><b>METHODS</b>This study involved 30 cases of benign prostatic hyperplasia (BPH) and another 30 cases of PCa with different PSADTZ values. Using a data imaging and analysis system, we determined the expression levels of Trp-p8 in BPH and PCa tissues and analyzed their correlation with PSADTZ.</p><p><b>RESULTS</b>The expression of Trp-p8 was weak or negative in the BPH but strong in the PCa tissue and even stronger in the PCa tissue with high PSADTZ (F = 34. 05, P < 0.05).</p><p><b>CONCLUSION</b>The Trp-p8 protein is expressed differently in BPH and PCa tissues of the PSA " grey zone" and its expression is positively correlated with PSADTZ. Determination of the Trp-p8 expression and PSADTZ contributes to the early diagnosis of prostate cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Hyperplasia
/
Prostatic Neoplasms
/
Biomarkers, Tumor
/
Prostate-Specific Antigen
/
Diagnosis
/
TRPM Cation Channels
/
Early Detection of Cancer
/
Metabolism
/
Methods
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2015
Type:
Article
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