Correlation of FOXA1 with the malignancy and progression of prostate cancer / 中华男科学杂志
National Journal of Andrology
;
(12): 414-419, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-276083
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship of the expression of FOXA1 in the prostate cancer (PCa) tissue with the Gleason score and clinical staging of PCa and with castration-resistant PCa (CRPC).</p><p><b>METHODS</b>Using the immunohistochemical method, we detected the expressions of FOXA1 and Ki-67 in the pathological sections of 35 cases of PCa and 21 cases of benign prostatic hyperplasia (BPH). Then we analyzed their correlation with the Gleason score and TNM staging of PCa and that with CRPC.</p><p><b>RESULTS</b>The positive expression of FOXA1 was significantly higher in the PCa than in the BPH tissue (P < 0.001) and was positively correlated with that of Ki-67 (P < 0.001) as well as with the Gleason score (P = 0.027) and clinical staging of PCa (P = 0.002), but showed no correlation with CRPC (P = 0.391).</p><p><b>CONCLUSION</b>The positive expression of FOXA1 is increased in PCa, most significantly in the advanced stage of the tumor.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostatic Hyperplasia
/
Prostatic Neoplasms
/
Disease Progression
/
Ki-67 Antigen
/
Hepatocyte Nuclear Factor 3-alpha
/
Neoplasm Grading
/
Metabolism
/
Neoplasm Proteins
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2015
Type:
Article
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