Combination of planning optimization formula with revision before manufacture process
Pharmaceutical Journal
;
: 20-23, 2000.
Article
in Vietnamese
| WPRIM
| ID: wpr-2761
ABSTRACT
The objectives of prospective process validation are to evaluate the key variables and their operational ranges and to predict the "worst cases" for each investigated variable. The targets of formulation design and optimization are to establish the quantitative relationships between input variables (ingredients/ processing conditions) and output variables (product properties). There are some intersectional ideas between validation and optimization as input-output relationships, quantifiable and predictable behaviours of input and output variables, constraints of independent and dependent variables, etc. The formulation design and optimization for paracetamol tablets, in combination with process prospective validation, using the optimization and what if prediction performed by INForm v3.0 as a frame work, was successfully done to (a) determine the critical variables as well as to estimate their optimized values, (b) to investigate the variable limits as well as to predict some worst cases
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmaceutical Preparations
/
Drug Industry
/
Formulary
Type of study:
Prognostic study
Language:
Vietnamese
Journal:
Pharmaceutical Journal
Year:
2000
Type:
Article
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