Research progress of the atypical kinetic profiles of cytochrome P450 enzymes / 药学学报
Acta Pharmaceutica Sinica
;
(12): 725-729, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-276253
ABSTRACT
Cytochrome P450 enzymes are composed of many isozymes and involved in the biotransformation of both exogenous and endogenous substances. A growing number of studies have found that the P450 enzymes do not always follow the classical Michaelis-Menten kinetics, but show atypical kinetic behavior, which is also the current research hotspot. In this paper, the category and mechanisms of atypical kinetics of the P450 enzyme were reviewed, providing theoretical basis for the research of enzyme kinetics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Protein Binding
/
Substrate Specificity
/
Benzoflavones
/
Binding Sites
/
Kinetics
/
Chemistry
/
Cytochrome P-450 Enzyme System
/
Enzyme Activation
/
Cytochrome P-450 CYP3A
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
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