Research progress of sodium-glucose co-transporter 2 inhibitors for treatment of type 2 diabetes / 药学学报
Acta Pharmaceutica Sinica
;
(12): 716-724, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-276254
ABSTRACT
Sodium-glucose co-transporters are a family of glucose transporter found in the intestinal mucosa of the small intestine (SGLT-2) and the proximal tubule of the nephron (SGLT-1 and SGLT-2). They contribute to renal glucose reabsorption and most of renal glucose (about 90%) is reabsorbed by SGLT-2 located in the proximal renal tubule. Selectively inhibiting activity of SGLT-2 is an innovative therapeutic strategy for treatment of type 2 diabetes by enhancing urinary glucose excretion from the body. Therefore SGLT-2 inhibitors are considered to be potential antidiabetic drugs with an unique mechanism. This review will highlight some recent advances and structure-activity relationships in the discovery and development of SGLT-2 inhibitors including O-glycoside, C-glycoside, C, O-spiro glycoside and non glycosides.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Structure-Activity Relationship
/
Benzhydryl Compounds
/
Molecular Structure
/
Chemistry
/
Diabetes Mellitus, Type 2
/
Drug Therapy
/
Sodium-Glucose Transporter 1
/
Sodium-Glucose Transporter 2
/
Glucosides
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
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