Brucine chitosan thermosensitive hydrogel for intra-articular injection / 药学学报
Acta Pharmaceutica Sinica
;
(12): 652-656, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-276264
ABSTRACT
The aim of this study was to develop a sustained release converse thermosensitive hydrogel for intra-articular injection using chitosan-glycerol-borax as matrix, its physical properties and biocompatibility were investigated. Taking gelation time and gelation condition as index, the influence of concentration of chitosan, ratio of chitosan to glycerol, pH on physical properties of hydrogel were investigated. And then the in vitro drug release, rheological properties and biocompatibility were studied. The thermosensitive hydrogel flows easily at room temperature and turns to gelation at body temperature, which can certainly prolong the release of drug and has good biocompatibility.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Rheology
/
Seeds
/
Strychnine
/
Surface Properties
/
Synaptic Membranes
/
Temperature
/
Materials Testing
/
Chemistry
/
Rats, Sprague-Dawley
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
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