Pharmacokinetic variation of ofloxacin based on gender-related difference in the expression of multidrug resistance-associated protein (Abcc2/Mrp2) in rat kidney / 药学学报
Acta Pharmaceutica Sinica
;
(12): 624-629, 2012.
Article
in English
| WPRIM
| ID: wpr-276269
ABSTRACT
The present study aimed to investigate the pharmacokinetic variation of ofloxacin based on gender-related difference in the expression of multidrug resistance-associated protein (Abcc2/Mrp2) in rat kidney. The concentrations of ofloxacin in rat plasma and urine were determined after tail vein administration (30 mg x kg(-1)) by high-performance liquid chromatography (HPLC) method. Expression of Mrp2 in kidney of male and female rats was qualitatively and quantitatively detected by immunohistochemistry and flow cytometry, separately. The results showed that AUC value of ofloxacin was lower in male rats than that in female rats and the total amount of ofloxacin excreted in the urine was higher in male rats than that in female rats. And the expression of Mrp2 in male rat kidney was higher than that in female rats. All results suggested that gender-related differences in pharmacokinetics of ofloxacin may be attributed to the differences in the expression of Mrp2 in kidney of male and female rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urine
/
Blood
/
Pharmacokinetics
/
Ofloxacin
/
Sex Characteristics
/
Rats, Wistar
/
ATP-Binding Cassette Transporters
/
Area Under Curve
/
Kidney
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
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