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Role of transporters in hepatic drug disposition / 药学学报
Acta Pharmaceutica Sinica ; (12): 565-572, 2012.
Article in Chinese | WPRIM | ID: wpr-276279
ABSTRACT
Liver is regarded as one of the most important organs for drug clearance in the body, which mediates both the metabolism and biliary excretion of drugs. Transporters are a class of functional membrane proteins and control the movement of substances into or out of cells. Transporters, which are extensively expressed in the liver, play important roles in the drug hepatic disposition by regulating the uptake of drugs from blood into hepatocytes or the efflux of drugs and their metabolites into bile. In this review, the localization, functions and substrate selectivity of the major transporters in the liver will be summarized, and the impacts of these transporters on drug hepatic disposition, the potential drug-drug interactions as well as their genetic polymorphisms will also be reviewed.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Membrane Transport Proteins / Polymorphism, Genetic / Bile / Biological Transport / Pharmacokinetics / Metabolic Clearance Rate / ATP Binding Cassette Transporter, Subfamily B, Member 1 / ATP-Binding Cassette Transporters / Multidrug Resistance-Associated Proteins / Organic Anion Transporters Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Membrane Transport Proteins / Polymorphism, Genetic / Bile / Biological Transport / Pharmacokinetics / Metabolic Clearance Rate / ATP Binding Cassette Transporter, Subfamily B, Member 1 / ATP-Binding Cassette Transporters / Multidrug Resistance-Associated Proteins / Organic Anion Transporters Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2012 Type: Article