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Clinical and laboratory characteristics of anti-soluble liver antigen/liver-pancreas (SLA/LP) autoantibody positive liver disease patients / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 927-929, 2005.
Article in Chinese | WPRIM | ID: wpr-276305
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the clinical and laboratory features of anti-soluble liver antigen/liver-pancreas (SLA/LP) autoantibody positive patients with abnormal liver functions.</p><p><b>METHODS</b>From July 1999 to August 2004, 4928 serum samples from patients with abnormal liver functions (ALT >40 U/L) were collected. A series of autoantibody examinations were carried out. Clinical manifestations and laboratory findings of 8 patients with anti-SLA/LP autoantibody positive were reviewed.</p><p><b>RESULTS</b>Among the 5500 serum samples, 8 cases (6 females and 2 males) with positive anti-SLA/LP autoantibodies were found with complete clinical information. The age of the patients was (27-76) years old. The case histories were from 2 years to 10 years. Of the 8 patients, 6 cases had liver cirrhosis and HBsAg-negative and anti-HCV-negative, active, 1 case had liver cirrhosis with HBsAg-positive, but HBVDNA negative; 1 case had liver cirrhosis and anti-HCV positive, but HCV RNA negative. The 8 cases were all ANA positive with titers of 31320. Four cases were AMA positive and 2 among these 4 cases were M2 positive. The most frequent symptoms were fatigue, anorexia, nausea, jaundice, abdominal distention and edema of lower limbs. All patients had high hypergammaglobulinemia.</p><p><b>CONCLUSION</b>Anti-SLA/LP autoantibody was at a low detection rate in the study with females in preponderance, Clinical and laboratory characteristics of the 8 cases were consistent with those of the autoimmune hepatitis (AIH). Testing for anti-SLA autoantibodies helps in the diagnosis of AIH in many patients who may otherwise be misdiagnosed.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancreas / Autoantibodies / Autoantigens / Sequence Homology / Hepatitis, Autoimmune / Diagnosis / Allergy and Immunology Type of study: Diagnostic study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hepatology Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancreas / Autoantibodies / Autoantigens / Sequence Homology / Hepatitis, Autoimmune / Diagnosis / Allergy and Immunology Type of study: Diagnostic study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hepatology Year: 2005 Type: Article