Cyclophilin A: A Mediator of Cardiovascular Pathology
Journal of the Korean Society of Hypertension
;
: 133-147, 2011.
Article
in English
| WPRIM
| ID: wpr-27661
ABSTRACT
Cyclophilin A (CyPA) is a 17 kDa, ubiquitously expressed multifunctional protein that possesses peptidylprolyl cis-trans isomerase activity and scaffold function. Its expression is increased in inflammatory conditions including rheumatoid arthritis, autoimmune disease and cancer. Intracellular CyPA regulates protein trafficking, signal transduction, transcription regulation and the activity of certain other proteins. Secreted CyPA activates cardiovascular cells resulting in a variety of cardiovascular diseases; including vascular remodeling, abdominal aortic aneurysms formation, atherosclerosis, cardiac hypertrophy and myocardial ischemic reperfusion injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Rheumatoid
/
Autoimmune Diseases
/
Cardiovascular Diseases
/
Myocardial Reperfusion Injury
/
Signal Transduction
/
Proteins
/
Aortic Aneurysm, Abdominal
/
Cardiomegaly
/
Oxidative Stress
/
Cyclophilins
Language:
English
Journal:
Journal of the Korean Society of Hypertension
Year:
2011
Type:
Article
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