The effect of huanglian jiedu tang on Alzheimer's disease and its influence on cytokines / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effect of huanglian jiedu tang on Alzheimer' s disease, and its influence on cytokines.</p><p><b>METHOD</b>AD rats models were made by A beta injection, and then water-maze tests were made to investigate the study and memory ability. TNF-alpha, INF-gamma and IL-2 were examined by ELISA. After treatment with huanglian jiedu tang, the rats were evaluated again.</p><p><b>RESULT</b>After A beta injection, the study and memory ability of the rats was decreased. By the treatment with huanglian jiedu tang, it was improved (P < 0.01); TNF-alpha, INF-gamma and IL-2 levels of AD rats were higher than those in control group (P < 0.01); after treatment the levels came down (P < 0.01).</p><p><b>CONCLUSION</b>Huanglian jiedu tang can improve the study and memory ability of AD rats by changing their immune state.</p>